RAS -> MEK Apoptosis -| MEK IL2RAT -> IL2RA IL2RA -| IL2RA IL2 -> IL2RA Apoptosis -| IL2RA Apoptosis -| GPCR S1P -> GPCR PI3K -> NFAT Apoptosis -| NFAT Stimuli -> IFNG SMAD -| IFNG IL2 -> IFNG Apoptosis -| IFNG IFNGT -> IFNG IL15 -> IFNG P2 -| IFNG Ceramide -| S1P Apoptosis -| S1P SPHK1 -> S1P Apoptosis -| CTLA4 TCR -> CTLA4 STAT3 -> Proliferation Apoptosis -| Proliferation P27 -| Proliferation CREB -> GZMB IFNG -> GZMB Apoptosis -| GZMB TBET -> GZMB Apoptosis -| Ceramide S1P -| Ceramide Fas -> Ceramide IFNG -> P2 Apoptosis -| P2 P2 -> P2 Stimuli2 -| P2 Apoptosis -| STAT3 JAK -> STAT3 IL2RB -> MCL1 DISC -| MCL1 STAT3 -> MCL1 PI3K -> MCL1 NFKB -> MCL1 Apoptosis -| MCL1 ERK -> IL2RBT Apoptosis -| IL2RBT TBET -> IL2RBT PI3K -> TPL2 TAX -> TPL2 Apoptosis -| TPL2 TNF -> TPL2 NFAT -> FasL STAT3 -> FasL ERK -> FasL Apoptosis -| FasL NFKB -> FasL PLCG1 -> RAS Apoptosis -| RAS GRB2 -> RAS GAP -| RAS DISC -> Caspase BID -> Caspase GZMB -> Caspase Apoptosis -| Caspase TRADD -> Caspase IAP -| Caspase Apoptosis -| SMAD GPCR -> SMAD TPL2 -> NFKB PI3K -> NFKB FLIP -> NFKB Apoptosis -| NFKB TRADD -> NFKB IAP -> NFKB A20 -| TRADD TNF -> TRADD Apoptosis -| TRADD IAP -| TRADD RAS -> PI3K Apoptosis -| PI3K PDGFR -> PI3K IL2 -| SOCS Apoptosis -| SOCS IL15 -| SOCS JAK -> SOCS FasL -> Fas sFas -| Fas FasT -> Fas Apoptosis -| Fas Apoptosis -| TNF NFKB -> TNF Stimuli -> TCR Apoptosis -| TCR CTLA4 -| TCR Apoptosis -| SPHK1 PDGFR -> SPHK1 IL2RB -> LCK CD45 -> LCK Apoptosis -| LCK ZAP70 -| LCK TCR -> LCK Caspase -> BID GZMB -> BID Apoptosis -| BID BclxL -| BID MCL1 -| BID FasT -> DISC Ceramide -> DISC IL2 -> DISC FLIP -| DISC Apoptosis -| DISC Fas -> DISC IL2 -| GAP RAS -> GAP Apoptosis -| GAP PDGFR -> GAP GAP -> GAP IL15 -| GAP FYN -> Cytoskeleton_signaling Apoptosis -| Cytoskeleton_signaling Caspase -> Apoptosis Apoptosis -> Apoptosis MEK -> ERK PI3K -> ERK Apoptosis -| ERK FYN -| ZAP70 Apoptosis -| ZAP70 LCK -> ZAP70 IL2RB -> JAK IL2RA -> JAK CD45 -| JAK IFNG -> JAK Apoptosis -| JAK RANTES -> JAK SOCS -| JAK FasT -> sFas S1P -> sFas Apoptosis -| sFas NFAT -> IL2 STAT3 -> IL2 Apoptosis -| IL2 NFKB -> IL2 TBET -| IL2 DISC -| BclxL STAT3 -> BclxL BID -| BclxL GZMB -| BclxL Apoptosis -| BclxL NFKB -> BclxL S1P -> PDGFR Apoptosis -| PDGFR PDGF -> PDGFR NFKB -> RANTES Apoptosis -| RANTES NFKB -> FasT Apoptosis -| FasT DISC -| FLIP CREB -> FLIP IFNG -> FLIP Apoptosis -| FLIP NFKB -> FLIP STAT3 -> P27 Apoptosis -| P27 Apoptosis -| PLCG1 GRB2 -> PLCG1 PDGFR -> PLCG1 IL2RB -> FYN Apoptosis -| FYN TCR -> FYN NFAT -> IFNGT STAT3 -> IFNGT Apoptosis -| IFNGT TBET -> IFNGT IL2 -> IL2RAT STAT3 -> IL2RAT NFKB -> IL2RAT Apoptosis -| IL2RAT BID -| IAP Apoptosis -| IAP NFKB -> IAP IL2RBT -> IL2RB IL2 -> IL2RB Apoptosis -| IL2RB IL15 -> IL2RB Apoptosis -| TBET TBET -> TBET JAK -> TBET Apoptosis -| A20 NFKB -> A20 IL2RB -> GRB2 Apoptosis -| GRB2 ZAP70 -> GRB2 ERK -> CREB IFNG -> CREB Apoptosis -| CREB $A20: (NFKB & !Apoptosis) $Apoptosis: (Apoptosis | Caspase) $BID: ((GZMB & !((BclxL | Apoptosis) | MCL1)) | (Caspase & !((BclxL | Apoptosis) | MCL1))) $BclxL: ((STAT3 & !(((Apoptosis | DISC) | BID) | GZMB)) | (NFKB & !(((Apoptosis | DISC) | BID) | GZMB))) $CREB: ((ERK & IFNG) & !Apoptosis) $CTLA4: (TCR & !Apoptosis) $Caspase: ((((TRADD & BID) & !(Apoptosis | IAP)) | ((GZMB & BID) & !(Apoptosis | IAP))) | (DISC & !Apoptosis)) $Ceramide: (Fas & !(Apoptosis | S1P)) $Cytoskeleton_signaling: (FYN & !Apoptosis) $DISC: ((FasT & (((Fas & !FLIP) | Ceramide) | (IL2 & Fas))) & !Apoptosis) $ERK: ((MEK & PI3K) & !Apoptosis) $FLIP: ((NFKB & !(Apoptosis | DISC)) | ((CREB & IFNG) & !(Apoptosis | DISC))) $FYN: ((TCR & !Apoptosis) | (IL2RB & !Apoptosis)) $Fas: ((FasT & FasL) & !(sFas | Apoptosis)) $FasL: ((((NFAT & !Apoptosis) | (STAT3 & !Apoptosis)) | (NFKB & !Apoptosis)) | (ERK & !Apoptosis)) $FasT: (NFKB & !Apoptosis) $GAP: (((PDGFR & GAP) & !((IL2 | Apoptosis) | IL15)) | (RAS & !((IL2 | Apoptosis) | IL15))) $GPCR: (S1P & !Apoptosis) $GRB2: ((IL2RB & !Apoptosis) | (ZAP70 & !Apoptosis)) $GZMB: ((TBET & !Apoptosis) | ((CREB & IFNG) & !Apoptosis)) $IAP: (NFKB & !(Apoptosis | BID)) $IFNG: ((((IL15 & IFNGT) & !((Apoptosis | P2) | SMAD)) | ((Stimuli & IFNGT) & !((Apoptosis | P2) | SMAD))) | ((IL2 & IFNGT) & !((Apoptosis | P2) | SMAD))) $IFNGT: (((TBET & !Apoptosis) | (NFAT & !Apoptosis)) | (STAT3 & !Apoptosis)) $IL2: (((NFKB & !(Apoptosis | TBET)) | (STAT3 & !(Apoptosis | TBET))) | (NFAT & !(Apoptosis | TBET))) $IL2RA: ((IL2 & IL2RAT) & !(IL2RA | Apoptosis)) $IL2RAT: ((IL2 & (STAT3 | NFKB)) & !Apoptosis) $IL2RB: ((IL2RBT & (IL2 | IL15)) & !Apoptosis) $IL2RBT: ((ERK & TBET) & !Apoptosis) $JAK: ((((RANTES & !((CD45 | Apoptosis) | SOCS)) | (IL2RA & !((CD45 | Apoptosis) | SOCS))) | (IFNG & !((CD45 | Apoptosis) | SOCS))) | (IL2RB & !((CD45 | Apoptosis) | SOCS))) $LCK: (((CD45 & !Apoptosis) | (IL2RB & !(Apoptosis | ZAP70))) | (TCR & !(Apoptosis | ZAP70))) $MCL1: ((IL2RB & ((STAT3 & PI3K) & NFKB)) & !(Apoptosis | DISC)) $MEK: (RAS & !Apoptosis) $NFAT: (PI3K & !Apoptosis) $NFKB: (((PI3K & !Apoptosis) | (TPL2 & !Apoptosis)) | ((FLIP & (TRADD & IAP)) & !Apoptosis)) $P2: ((P2 & !(Apoptosis | Stimuli2)) | (IFNG & !(Apoptosis | Stimuli2))) $P27: (STAT3 & !Apoptosis) $PDGFR: ((S1P & !Apoptosis) | (PDGF & !Apoptosis)) $PI3K: ((PDGFR & !Apoptosis) | (RAS & !Apoptosis)) $PLCG1: ((GRB2 & !Apoptosis) | (PDGFR & !Apoptosis)) $Proliferation: (STAT3 & !(P27 | Apoptosis)) $RANTES: (NFKB & !Apoptosis) $RAS: ((PLCG1 & !(Apoptosis | GAP)) | (GRB2 & !(Apoptosis | GAP))) $S1P: (SPHK1 & !(Ceramide | Apoptosis)) $SMAD: (GPCR & !Apoptosis) $SOCS: (JAK & !((IL2 | IL15) | Apoptosis)) $SPHK1: (PDGFR & !Apoptosis) $STAT3: (JAK & !Apoptosis) $TBET: ((TBET & !Apoptosis) | (JAK & !Apoptosis)) $TCR: (Stimuli & !(Apoptosis | CTLA4)) $TNF: (NFKB & !Apoptosis) $TPL2: (((PI3K & TNF) & !Apoptosis) | (TAX & !Apoptosis)) $TRADD: (TNF & !((A20 | Apoptosis) | IAP)) $ZAP70: (LCK & !(FYN | Apoptosis)) $sFas: ((FasT & S1P) & !Apoptosis)